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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2020-11-09T23:09:45.0836128+00:00 -->
<!-- Version            : 5.0.1.513 -->
<!-- Package ID         : ad050a1bb1f140f3966ddebc026d5da8 -->
<!-- Copyright (c) 2020 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="om_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_CapitalizedContractCostAmortizationPeriodDescription" name="CapitalizedContractCostAmortizationPeriodDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_FinancialLiabilitiesAmortizedCosts" name="FinancialLiabilitiesAmortizedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_FinancialLiabilitiesAccumulatedGrossUnrealizedGainBeforeTax" name="FinancialLiabilitiesAccumulatedGrossUnrealizedGainBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="om_FinancialLiabilitiesAccumulatedGrossUnrealizedLossBeforeTax" name="FinancialLiabilitiesAccumulatedGrossUnrealizedLossBeforeTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_RedeemableConvertiblePreferredStockWarrantLiabilityMember" name="RedeemableConvertiblePreferredStockWarrantLiabilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_PrepaidInsuranceNoncurrent" name="PrepaidInsuranceNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="om_AccruedInventoryCurrent" name="AccruedInventoryCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_AccruedResearchAndDevelopmentExpenses" name="AccruedResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_PerceptiveTermLoanMember" name="PerceptiveTermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_SiliconValleyBankTermLoanMember" name="SiliconValleyBankTermLoanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_PaymentForDebtPrepaymentAccruedInterestAndExitFees" name="PaymentForDebtPrepaymentAccruedInterestAndExitFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_DebtInstrumentInterestOnlyPaymentsYearAndMonth" name="DebtInstrumentInterestOnlyPaymentsYearAndMonth" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_DebtInstrumentPrincipalPaymentTermAfterInterestOnlyPeriodExpires" name="DebtInstrumentPrincipalPaymentTermAfterInterestOnlyPeriodExpires" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_DebtInstrumentFinalPaymentFeePercentage" name="DebtInstrumentFinalPaymentFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_DebtInstrumentPrepaymentFeePercentage" name="DebtInstrumentPrepaymentFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_PercentageOfLimitationOnPledgesOfCapitalStockOfForeignSubsidiaries" name="PercentageOfLimitationOnPledgesOfCapitalStockOfForeignSubsidiaries" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="om_OtherDebtIssuanceCosts" name="OtherDebtIssuanceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="om_StockIssuedDuringPeriodSharesIssuedOnExerciseOfWarrants" name="StockIssuedDuringPeriodSharesIssuedOnExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_CommonStockWarrantsExpirationDate" name="CommonStockWarrantsExpirationDate" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_ConversionOfRedeemableConvertiblePreferredStockWarrantsToCommonStock" name="ConversionOfRedeemableConvertiblePreferredStockWarrantsToCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_SeriesARedeemableConvertiblePreferredStockWarrantsMember" name="SeriesARedeemableConvertiblePreferredStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_SeriesBRedeemableConvertiblePreferredStockWarrantsMember" name="SeriesBRedeemableConvertiblePreferredStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_SeriesCRedeemableConvertiblePreferredStockWarrantsMember" name="SeriesCRedeemableConvertiblePreferredStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_PreferredStockWarrantsOutstanding" name="PreferredStockWarrantsOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="om_TwoThousandTwentyEquityIncentivePlanMember" name="TwoThousandTwentyEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_EmployeesSharePurchasePlanMember" name="EmployeesSharePurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_EmployeesAndExecutiveOfficersMember" name="EmployeesAndExecutiveOfficersMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfAdditionalSharesAvailableForIssuance" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfAdditionalSharesAvailableForIssuance" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_ShareBasedCompensationArrangementByShareBasedPaymentAwardInitialOfferingDate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardInitialOfferingDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantDateFairValue" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="om_OptionsToPurchaseCommonStockMember" name="OptionsToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_WarrantsToPurchaseRedeemableConvertiblePreferredStockMember" name="WarrantsToPurchaseRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="om_WarrantsToPurchaseCommonStockMember" name="WarrantsToPurchaseCommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
